| Rank | Ticker | Company | Weight | Country | Market Cap | Industry |
|---|---|---|---|---|---|---|
| 1 | NTRA |   | 11.41% | United States | $6.18b | Diagnostics & Research |
| 2 | SRPT |  | 6.74% | United States | $10.54b | Biotechnology |
| 3 | ALNY |  | 5.91% | United States | $26b | Biotechnology |
| 4 | RARE |  | 5.02% | United States | $2.91b | Biotechnology |
| 5 | CRSP |  | 4.78% | United States | $3.96b | Biotechnology |
| 6 | 1548 |  | 4.7% | Hong Kong | Biotechnology | |
| 7 | TECH |  | 4.63% | United States | $11.32b | Biotechnology |
| 8 | A |  | 4.6% | United States | $33b | Diagnostics & Research |
| 9 | QGEN |  | 4.52% | United States | $9.53b | Diagnostics & Research |
| 10 | BMRN |  | 4.36% | United States | $17.17b | Biotechnology |
| 11 | MYGN |  | 3.9% | United States | $1.33b | Diagnostics & Research |
| 12 | ARWR |  | 3.88% | United States | $3.15b | Biotechnology |
| 13 | VRTX |  | 3.67% | United States | $89b | Biotechnology |
| 14 | TXG |  | 3.42% | United States | $4.82b | Health Information Services |
| 15 | VCYT |  | 3.16% | United States | $1.83b | Biotechnology |
| 16 | BNTX |  | 2.87% | United States | $28b | Biotechnology |
| 17 | RCKT |  | 2.72% | United States | $1.21b | Biotechnology |
| 18 | BEAM |  | 2.41% | United States | $1.90b | Biotechnology |
| 19 | GILD |  | 2.36% | United States | $96b | Drug Manufacturers-General |
| 20 | ILMN |  | 2.15% | United States | $24b | Diagnostics & Research |
| 21 | NTLA |  | 2.08% | United States | $3.27b | Biotechnology |
| 22 | MRNA |  |